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Endoplasmic Reticulum Stress in Arterial Smooth Muscle Cells: A Novel Regulator of Vascular Disease

[ Vol. 13 , Issue. 2 ]

Author(s):

Catherine M. Shanahan and Malgorzata Furmanik   Pages 94 - 105 ( 12 )

Abstract:


Cardiovascular disease continues to be the leading cause of death in industrialised societies. The idea that the arterial smooth muscle cell (ASMC) plays a key role in regulating many vascular pathologies has been gaining importance, as has the realisation that not enough is known about the pathological cellular mechanisms regulating ASMC function in vascular remodelling. In the past decade endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been recognised as a stress response underlying many physiological and pathological processes in various vascular cell types. Here we summarise what is known about how ER stress signalling regulates phenotypic switching, trans/dedifferentiation and apoptosis of ASMCs and contributes to atherosclerosis, hypertension, aneurysms and vascular calcification.

Keywords:

ER stress, vascular smooth muscle cell, vascular calcification, atherosclerosis.

Affiliation:

King’s College London, Cardiovascular Division, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, British Heart Foundation Centre of Research Excellence, Cardiovascular Division, James Black Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU

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