Sethumadhavan Vijayan*, David S. Barmby, Ian R. Pearson, Andrew G. Davies, Stephen B. Wheatcroft and Mohan Sivananthan Pages 232 - 243 ( 12 )
Background: Contemporary management of coronary disease focuses on the treatment of stenoses in the major epicardial vessels. However, myocardial blood flow is known to be contingent on a range of factors in addition to the patency of the epicardial vessels. These include anatomical and physiological factors such as the extent of myocardium supplied by the vessel, systemic blood pressure, the natural variation in vascular tone in response to physiological needs which allows for coronary autoregulation and pathological factors such as the presence of downstream obstruction to flow due to disease of the small coronary vessels or myocardium. The assessment of clinical effectiveness and adequacy of coronary revascularisation requires the ability to comprehensively and accurately assess and measure myocardial perfusion.Conclusion: In this article, we review the current methods of evaluating coronary blood flow and myocardial perfusion in the cardiac catheterisation laboratory.
Coronary physiology, microvascular resistance, coronary blood flow measurement, myocardial blood flow, autoregulation, stenoses, epicardial vessels.
Interventional Fellow, Department of Cardiology, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds