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Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart

[ Vol. 15 , Issue. 3 ]

Author(s):

Leonid N. Maslov*, Sergey Y. Tsibulnikov, Ekaterina S. Prokudina, Sergey V. Popov, Alla A. Boshchenko, Nirmal Singh, Yi Zhang and Peter R. Oeltgen   Pages 177 - 187 ( 11 )

Abstract:


The hypothetical trigger of remote postconditioning (RPost) of the heart is the highmolecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study. In signaling mechanism RPost, kinases are involved: protein kinase C, PI3, Akt, JAK. The hypothetical end effector of RPost is aldehyde dehydrogenase-2, the transcription factors STAT, Nrf2, and also the BKCa channel.

Keywords:

Heart, ischemia, reperfusion, remote postconditioning, humoral factor, autonomic nervous system, signaling, end effector.

Affiliation:

Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Department of Physiology, Hebei Medical University, Shijiazhuang, Department of Pathology, University of Kentucky College of Medicine, Lexington, KY

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