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Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart

[ Vol. 15 , Issue. 4 ]

Author(s):

Alexandr S. Gorbunov, Leonid N. Maslov*, Amteshwar S. Jaggi, Nirmal Singh, Luciano De Petrocellis, Alla A. Boshchenko, Ali Roohbakhsh, Vladimir V. Bezuglov and Peter R. Oeltgen   Pages 244 - 251 ( 8 )

Abstract:


Transient receptor potential vanilloid channel 2 (TRPV2) is required for normal cardiac contractility. The stimulation of TRPV1 in isolated cardiomyocytes can aggravate the effect of hypoxia/ reoxygenation (H/R) on H9C2 cells. The knockout of the TRPV1 gene promotes increased tolerance of the isolated perfused heart to the impact of ischemia/reperfusion (I/R). However, activation of TRPV1 increases the resistance of the heart to I/R due to calcitonin gene-related peptide (CGRP) release from afferent nerve endings. It has been established that TRPV1 and TRPV2 are involved in the pathogenesis of myocardial infarction and, in all likelihood, ensure the cardiac tolerance to the ischemia/reperfusion. It has also been documented that the activation of TRPV4 negatively affects the stability of cardiomyocytes to the H/R. The blockade of TRPV4 can be considered as a new approach to the prevention of I/R injury of the heart. Studies also indicate that TRPV1 is involved in the pathogenesis of cardiac hypertrophy and that TRPV2 channels participate in the pathogenesis of dilated cardiomyopathy. Excessive expression of TRPV2 leads to chronic Ca2+- overload of cardiomyocytes, which may contribute to the development of cardiomyopathy.

Keywords:

Heart, TRPV1, TRPV2, TRPV4, cardiomyocytes, cardiomyopathy.

Affiliation:

Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of The Russian Academy of Science, Tomsk, Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of The Russian Academy of Science, Tomsk, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli (NA), Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of The Russian Academy of Science, Tomsk, Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Institute of Bioorganic Chemistry, acad. M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow, Department of Pathology, University of Kentucky College of Medicine, Lexington, KY

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