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Syndrome of Supine Hypertension with Orthostatic Hypotension: Pathophysiology and Clinical Approach

[ Vol. 16 , Issue. 1 ]

Author(s):

Aamir Ahmed, Mohammed Ruzieh*, Shaffi Kanjwal and Khalil Kanjwal   Pages 48 - 54 ( 7 )

Abstract:


This article is intended to provide guidance and clinical considerations for physicians managing patients suffering from supine hypertension with orthostatic hypotension, referred to as “SH-OH”. We review the normal physiologic response to orthostasis, focusing on the appropriate changes to autonomic output in this state. Autonomic failure is discussed with a generalized overview of the disease and examination of specific syndromes that help shed light on the pathophysiology of SH-OH. The goal of this review is to provide a better framework for clinical evaluation of these patients, review treatment options, and ultimately work toward achieving a better quality of life for patients afflicted with this disease.

Keywords:

Orthostatic hypotension, supine hypertension, autonomic failure, dysautonomia, blood pressure, orthostatic posture.

Affiliation:

Department of Internal Medicine, Rush University, Chicago, IL 60612, Penn State Heart and Vascular Institute. Hershey, PA 17033, St Mary's of Michigan, McLaren Greater Lansing Hospital, Lansing, MI 48910

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