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Article Details


Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment

[ Vol. 16 , Issue. 3 ]

Author(s):

Vadim V. Genkel*, Alla S. Kuznetcova and Igor I. Shaposhnik   Pages 187 - 197 ( 11 )

Abstract:


The article provides an overview of current views on the role of biomechanical forces in the pathogenesis of atherosclerosis. The importance of biomechanical forces in maintaining vascular homeostasis is considered. We provide descriptions of mechanosensing and mechanotransduction. The roles of wall shear stress and circumferential wall stress in the initiation, progression and destabilization of atherosclerotic plaque are described. The data on the possibilities of assessing biomechanical factors in clinical practice and the clinical significance of this approach are presented. The article concludes with a discussion on current therapeutic approaches based on the modulation of biomechanical forces.

Keywords:

Atherosclerosis, wall shear stress, peripheral artery disease, circumferential wall stress, mechanosensing, plaque progression.

Affiliation:

Department of Internal Medicine, Federal State Budgetary Educational Institution of Higher Education “South-Ural State Medical University” of the Ministry of Healthcare of the Russian Federation, Chelyabinsk, Department of Hospital Therapy Federal State Budgetary Educational Institution of Higher Education “South-Ural State Medical University” of the Ministry of Healthcare of the Russian Federation, Chelyabinsk, Department of Internal Medicine, Federal State Budgetary Educational Institution of Higher Education “South-Ural State Medical University” of the Ministry of Healthcare of the Russian Federation, Chelyabinsk

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