Juan A Siordia* Pages 1 - 5 ( 5 )
Background: Aortic aneurysms are worrisome because of their predisposition to dissection and rupture. Beta-blockers are considered first line therapy for aortic aneurysms. The following meta-analysis assess if beta-blockers diminish aortic aneurysm growth.
Methods: A literature search was performed to collect information on clinical trials that have assessed aortic aneurysm growth between beta-blockers and placebo. The primary endpoint was aortic aneurysm growth rate per year. A forest plot with a random effects model was used for analysis.
Results: Eight clinical trials were included in the analysis. Beta-blockers showed a statistically non-significant effect on aortic aneurysm growth (standard mean difference -0.44; 95% CI [-0.44, 0.00]).
Conclusion: Beta-blockers do not significantly influence aortic aneurysm growth. Further studies are required to find a suitable medical therapy to reduce growth rates.
Beta-Blocker, Aortic Aneurysm, Aorta, Medical Therapy, Blood Pressure, Meta-analysis
Department of Internal Medicine, Banner-University Medical Center, University of Arizona, 1501 N Campbell Ave, Tucson, AZ